No associations were found between mental health and TL. A one-point increment in the lifestyle score was associated with lower odds (ranging from 0.56 to 0.74) for all studied mental health outcomes and with a 1.74% (95% CI: 0.11, 3.40%) longer TL and 4.07% (95% CI: 2.01, 6.17%) higher mtDNAc. The average age (SD) of the study population was 49.9 (17.5) years, and 48.8% were men.
Generalised linear mixed models were used while adjusting for a priori chosen covariates. On a subset of 739 participants, leucocyte TL and mtDNAc were assessed using qPCR. A lifestyle score integrating diet, physical activity, smoking status, alcohol consumption and BMI was created and validated. Mental health and well-being outcomes included psychological and severe psychological distress, vitality, life satisfaction, self-perceived health, depressive and generalised anxiety disorder and suicidal ideation. In this study, 6054 adults from the 2018 Belgian Health Interview Survey (BHIS) were included. Here, we studied the mediation of different health behaviours or lifestyle factors on mental health and its effect on core markers of ageing: telomere length (TL) and mitochondrial DNA content (mtDNAc).
Also, the underlying pathways of how lifestyle might affect our health are still under debate. Studies often evaluate mental health and well-being in association with individual health behaviours although evaluating multiple health behaviours that co-occur in real life may reveal important insights into the overall association.
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